胡永飞

个人简介

胡永飞，男，博士，教授，硕士/博士生导师。2010年7月获中国科学院微生物研究所微生物学博士学位，毕业后留所任助理研究员、副研究员。2018年6月以“杰出人才”引进中国农业大学，任动物科学技术学院教授。

作为主要参加人和课题主持人先后承担了国家高技术研究发展计划（863）、卫生部科技重大专项、国家重点基础研究发展计划（973）、国家重点研发计划、国家自然科学基金和北京市自然科学基金等项目。2010以来，发表SCI论文42篇；其中以第一作者或通讯作者在Nature Communications、The Lancet Infectious Diseases、PLoS Pathogens等杂志上发表SCI论文28篇；国内核心期刊论文12篇，申请国内发明专利4项；参编国家卫计委“十二五”规划教材1部，特邀主编《生物工程学报》专刊1期，副主编科普读物1部。2015年入选中国科学院青年创新促进会会员；2016年入选中国研究型医院学会空间微生物学与感染专业委员会青年委员。JAC、AAC等多个SCI杂志同行评议审稿人；2017年至今任Frontiers in Cellular and Infection Microbiology杂志审稿编委。

学习与工作经历

2000/09-2004/07，辽宁大学生命科学院，生物科学专业，学士

2004/09-2007/07，辽宁大学生命科学院，微生物学专业，硕士

2007/09-2010/07，中国科学院微生物研究所，微生物学专业，博士

2010/07-2014/08，中国科学院微生物研究所，病原室，助理研究员

2014/09-2018/05，中国科学院微生物研究所，病原室，副研究员

2018/06至今，中国农业大学，动物科学技术学院，教授

研究方向

肠道菌群与动物营养和免疫调控机制；新型益生菌及酶资源挖掘与利用；噬菌体与宿主共进化机制及其替抗应用；细菌耐药与耐药传播机制。

发表论文

1. Wang, Y.^#, Hu, Y.^#, Cao, J., Bi, Y., Lv, N., Liu, F., Liang, S., Shi, Y., Jiao, X., Gao, G. F., & Zhu, B. 2019. Antibiotic resistance gene reservoir in live poultry markets. J Infect. (online).

2. Hu, Y., Feng, Y., Wu, J., Liu, F., Zhang, Z., Hao, Y., Liang, S., Li, B., Li, J., Lv, N., Xu, Y., Zhu, B., & Sun, Z. 2019. The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients. Frontiers in Cellular and Infection Microbiology, 9:90.

3. Xu, Y., Liu, F., Chen, S., Wu, J., Hu, Y., Zhu, B., & Sun, Z. 2018. In vivo evolution of drug-resistant Mycobacterium tuberculosis in patients during long-term treatment. BMC Genomics, 19(1): 640.

4. Liu, W. J.^#, Zou, R.^#, Hu, Y.^#, Zhao, M., Quan, C., Tan, S., Luo, K., Yuan, J., Zheng, H., Liu, J., Liu, M., Bi, Y., Yan, J., Zhu, B., Wang, D., Wu, G., Liu, L., Yuen, K. Y., Gao, G. F., & Liu, Y. 2018. Clinical, immunological and bacteriological characteristics of H7N9 patients nosocomially co-infected by Acinetobacter Baumannii: a case control study. BMC Infect Dis, 18(1): 664.

5. Alkasir, R., Ma, Y., Liu, F., Li, J., Lv, N., Xue, Y., Hu, Y.*, & Zhu, B*. 2018. Characterization and Transcriptome Analysis of Acinetobacter baumannii Persister Cells. Microb Drug Resist, 24(10): 1466-1474.

6. Zhang, C., Feng, Y., Liu, F., Jiang, H., Qu, Z., Lei, M., Wang, J., Zhang, B., Hu, Y., Ding, J., & Zhu, B. 2017. A Phage-Like IncY Plasmid Carrying the mcr-1 Gene in Escherichia coli from a Pig Farm in China. Antimicrob Agents Chemother, 61(3): e02035-16.

7. Lu, X.^#, Hu, Y.^#, Luo, M., Zhou, H., Wang, X., Du, Y., Li, Z., Xu, J., Zhu, B., Xu, X., & Kan, B. 2017. MCR-1.6, a New MCR Variant Carried by an IncP Plasmid in a Colistin-Resistant Salmonella enterica Serovar Typhimurium Isolate from a Healthy Individual. Antimicrob Agents Chemother, 61(5): e02632-16.

8. Hu, Y.*, Gao, G. F., & Zhu, B*. 2017. The antibiotic resistome: gene flow in environments, animals and human beings. Front Med, 11(2): 161-168.

9. Hu, Y., & Zhu, B. 2016. The Human Gut Antibiotic Resistome in the Metagenomic Era: Progress and Perspectives. Infect Dis Transl Med, 2(1): 41-47.

10. Hu, Y., Yang, X., Li, J., Lv, N., Liu, F., Wu, J., Lin, I. Y., Wu, N., Weimer, B. C., Gao, G. F., Liu, Y., & Zhu, B. 2016. The Bacterial Mobile Resistome Transfer Network Connecting the Animal and Human Microbiomes. Appl Environ Microbiol, 82(22): 6672-6681.

11. Hu, Y., Liu, F., Lin, I. Y., Gao, G. F., & Zhu, B. 2016. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis, 16(2): 146-147.

12. Gao, R.^#, Hu, Y.^#, Li, Z.^#, Sun, J.^#, Wang, Q., Lin, J., Ye, H., Liu, F., Srinivas, S., Li, D., Zhu, B., Liu, Y. H., Tian, G. B., & Feng, Y. 2016. Dissemination and Mechanism for the MCR-1 Colistin Resistance. PLoS Pathog, 12(11): e1005957.

13. Yang, X., Liu, D., Lv, N., Zhao, F., Liu, F., Zou, J., Chen, Y., Xiao, X., Wu, J., Liu, P., Gao, J., Hu, Y., Shi, Y., Liu, J., Zhang, R., Chen, C., Ma, J., Gao, G. F., & Zhu, B. 2015. TCRklass: a new K-string-based algorithm for human and mouse TCR repertoire characterization. J Immunol, 194(1): 446-454.

14. Luan, C., Xie, L., Yang, X., Miao, H., Lv, N., Zhang, R., Xiao, X., Hu, Y., Liu, Y., Wu, N., Zhu, Y., & Zhu, B. 2015. Dysbiosis of fungal microbiota in the intestinal mucosa of patients with colorectal adenomas. Sci Rep, 5: 7980.

15. Liu, F., Yang, X., Wang, Z., Nicklasson, M., Qadri, F., Yi, Y., Zhu, Y., Lv, N., Li, J., Zhang, R., Guo, H., Zhu, B., Sjoling, A.*, & Hu, Y*. 2015. Draft genomes of four enterotoxigenicEscherichia coli(ETEC) clinical isolates from China and Bangladesh. Gut Pathog, 7: 10.

16. Li, X., Wu, J., Han, J., Hu, Y., & Mi, K. 2015. Distinct Responses ofMycobacterium smegmatis to Exposure to Low and High Levels of Hydrogen Peroxide. PLoS One, 10(7): e0134595.

17. Li, H., Liu, F., Zhang, Y., Wang, X., Zhao, C., Chen, H., Zhang, F., Zhu, B., Hu, Y.*, & Wang, H.* 2015. Evolution of carbapenem-resistant Acinetobacter baumanniirevealed through whole-genome sequencing and comparative genomic analysis. Antimicrob Agents Chemother, 59(2): 1168-1176.

18. Hu, Y., Zhu, Y., Ma, Y., Liu, F., Lu, N., Yang, X., Luan, C., Yi, Y., & Zhu, B. 2015. Genomic insights into intrinsic and acquired drug resistance mechanisms in Achromobacter xylosoxidans. Antimicrob Agents Chemother, 59(2): 1152-1161.

19. Hu, Y.^#, Liu, Y^#., Li, J., Feng, Y., Lu, N., Zhu, B., & Xue, S. 2015. Structural and functional analysis of a low-temperature-active alkaline esterase from South China Sea marine sediment microbial metagenomic library. J Ind Microbiol Biotechnol, 42(11): 1449-1461.

20. Zhu, Y., Yi, Y., Liu, F., Lv, N., Yang, X., Li, J., Hu, Y.*, & Zhu, B*. 2014. Distribution and molecular profiling of class 1 integrons in MDR Acinetobacter baumannii isolates and whole genome-based analysis of antibiotic resistance mechanisms in a representative strain. Microbiol Res, 169(11): 811-816.

21. Yi, Y., Lu, N., Liu, F., Li, J., Zhang, R., Jia, L., Jing, H., Xia, H., Yang, Y., Zhu, B., Hu, Y.*, & Cui, Y*. 2014. Genome sequence and comparative analysis of aVibrio cholerae O139 strain E306 isolated from a cholera case in China. Gut Pathog, 6(1): 3.

22. Lu, N.^#, Hu, Y.^#, Zhu, L.^#, Yang, X., Yin, Y., Lei, F., Zhu, Y., Du, Q., Wang, X., Meng, Z., & Zhu, B. 2014. DNA microarray analysis reveals that antibiotic resistance-gene diversity in human gut microbiota is age related. Sci Rep, 4: 4302.

23. Liu, F., Zhu, Y., Yi, Y., Lu, N., Zhu, B.*, & Hu, Y*. 2014. Comparative genomic analysis of Acinetobacter baumanniiclinical isolates reveals extensive genomic variation and diverse antibiotic resistance determinants. BMC Genomics, 15: 1163.

24. Liu, F.^#, Hu, Y.^#, Wang, Q., Li, H. M., Gao, G. F., Liu, C. H., & Zhu, B. 2014. Comparative genomic analysis of Mycobacterium tuberculosis clinical isolates. BMC Genomics, 15: 469.

25. Li, X., Liu, F., Hu, Y., & Mi, K. 2014. Draft Genome Sequence of mc251, a Highly Hydrogen Peroxide-Resistant Mycobacterium smegmatis Mutant Strain. Genome Announc, 2(1): e00092-14.

26. Hu, Y., Yang, X., Lu, N., & Zhu, B. 2014. The abundance of antibiotic resistance genes in human guts has correlation to the consumption of antibiotics in animal. Gut Microbes, 5(2): 245-249.

27. Wu, N., Yang, X., Zhang, R., Li, J., Xiao, X., Hu, Y., Chen, Y., Yang, F., Lu, N., Wang, Z., Luan, C., Liu, Y., Wang, B., Xiang, C., Wang, Y., Zhao, F., Gao, G. F., Wang, S., Li, L., Zhang, H., & Zhu, B. 2013. Dysbiosis signature of fecal microbiota in colorectal cancer patients. Microb Ecol, 66(2): 462-470.

28. Li, B.^#, Hu, Y.^#, Wang, Q.^#, Yi, Y., Woo, P. C., Jing, H., Zhu, B., & Liu, C. H. 2013. Structural diversity of class 1 integrons and their associated gene cassettes in Klebsiella pneumoniae isolates from a hospital in China. PLoS One, 8(9): e75805.

29. Hu, Y.^#, Yang, X.^#, Qin, J., Lu, N., Cheng, G., Wu, N., Pan, Y., Li, J., Zhu, L., Wang, X., Meng, Z., Zhao, F., Liu, D., Ma, J., Qin, N., Xiang, C., Xiao, Y., Li, L., Yang, H., Wang, J., Yang, R., Gao, G. F., Wang, J., & Zhu, B. 2013. Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota. Nat Commun, 4: 2151.

30. Cheng, G., Hu, Y., Lu, N., Li, J., Wang, Z., Chen, Q., & Zhu, B. 2013. Identification of a novel fosfomycin-resistant UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from a soil metagenome. Biotechnol Lett, 35(2): 273-278.

31. Wu, N., Zhang, Y., Fu, J., Zhang, R., Feng, L., Hu, Y., Li, X., Lu, N., Zhao, X., Pan, Y., Li, J., Zhu, B., & Wan, K. 2012. Performance assessment of a novel two-step multiple displacement amplification-PCR assay for detection of Mycobacterium tuberculosis complex in sputum specimens. J Clin Microbiol, 50(4): 1443-1445.

32. Liu, C. H., Li, H. M., Lu, N., Wang, Q., Hu, Y. L., Yang, X., Hu, Y. F., Woo, P. C., Gao, G. F., & Zhu, B. 2012. Genomic sequence based scanning for drug resistance-associated mutations and evolutionary analysis of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. J Infect, 65(5): 412-422.

33. Hu, H.^#, Hu, Y.^#, Pan, Y., Liang, H., Wang, H., Wang, X., Hao, Q., Yang, X., Yang, X., Xiao, X., Luan, C., Yang, Y., Cui, Y., Yang, R., Gao, G. F., Song, Y., & Zhu, B. 2012. Novel plasmid and its variant harboring both a bla(NDM-1) gene and type IV secretion system in clinical isolates of Acinetobacter lwoffii. Antimicrob Agents Chemother, 56(4): 1698-1702.

34. Cheng, G., Hu, Y., Yin, Y., Yang, X., Xiang, C., Wang, B., Chen, Y., Yang, F., Lei, F., Wu, N., Lu, N., Li, J., Chen, Q., Li, L., & Zhu, B. 2012. Functional screening of antibiotic resistance genes from human gut microbiota reveals a novel gene fusion. FEMS Microbiol Lett, 336(1): 11-16.

35. Pan, Y., Yang, X., Li, J., Zhang, R., Hu, Y., Zhou, Y., Wang, J., & Zhu, B. 2011. Genome sequence of the Spinosyns-producing bacterium Saccharopolyspora spinosa NRRL 18395. J Bacteriol, 193(12): 3150-3151.

36. Pan, Y., Yang, X., Duan, J., Lu, N., Leung, A. S., Tran, V., Hu, Y., Wu, N., Liu, D., Wang, Z., Yu, X., Chen, C., Zhang, Y., Wan, K., Liu, J., & Zhu, B. 2011. Whole-genome sequences of four Mycobacterium bovis BCG vaccine strains. J Bacteriol, 193(12): 3152-3153.

37. Hu, Y.^#, Zhang, W.^#, Liang, H., Liu, L., Peng, G., Pan, Y., Yang, X., Zheng, B., Gao, G. F., Zhu, B., & Hu, H. 2011. Whole-genome sequence of a multidrug-resistant clinical isolate of Acinetobacter lwoffii. J Bacteriol, 193(19): 5549-5550.

38. Fu, C.^#, Hu, Y.^#, Xie, F., Guo, H., Ashforth, E. J., Polyak, S. W., Zhu, B., & Zhang, L. 2011. Molecular cloning and characterization of a new cold-active esterase from a deep-sea metagenomic library. Appl Microbiol Biotechnol, 90(3): 961-970.

39. Zhao, W., Zhong, Y., Yuan, H., Wang, J., Zheng, H., Wang, Y., Cen, X., Xu, F., Bai, J., Han, X., Lu, G., Zhu, Y., Shao, Z., Yan, H., Li, C., Peng, N., Zhang, Z., Zhang, Y., Lin, W., Fan, Y., Qin, Z., Hu, Y., Zhu, B., Wang, S., Ding, X., & Zhao, G. P. 2010. Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. Cell Res, 20(10): 1096-1108.