张炳坤

张炳坤，博士，博士生导师，中国农业大学动物科技学院副教授。长期致力于促进动物黏膜屏障功能健康发育的营养调控及其相关机制研究。中国畜牧兽医学会动物营养分会理事、北京畜牧兽医学会理事、World's Poultry Science Association (WPSA)、美国American Gastroenterological Association (AGA)会员等。曾在美国芝加哥大学（The University of Chicago）进行病原菌调控宿主肠道屏障功能作用机制合作研究。

承担和参与国家自然基金项目、973计划课题“胃肠道结构与功能的发育及其调节”、国家科技支撑项目、国家重点研发计划等国家级项目，获得北京高等学校“青年英才计划”支持。

获教育部科学技术进步一等奖和国家科学技术进步二等奖各1项，起草制定《产蛋后备鸡、产蛋鸡、肉用仔鸡配合饲料》、《玉米干全酒糟（玉米DDGS）》、蛋鸡、肉鸡配合饲料等国家或行业标准以及《饲料添加剂安全使用规范》，参编《家禽营养》、《动物免疫营养学》等著作，近期已在国际著名期刊Cell Host & Microbe 、Journal of Nutrition 、Journal of Nutritional Biochemistry、British Journal of Nutrition、Animal Feed Science & Technology、Poultry Science、Animal、Avian Pathology等期刊上发表论文二十余篇，申请授权发明专利3项。

研究方向

肠道屏障功能和黏膜免疫在肠炎中的作用；

肠道健康的营养调控；

畜禽产品品质的调节；

新型饲料添加剂开发与应用。

代表论文

Wei Wu, Zhibin Xiao, Wenyi An, Yuanyang Dong, Bingkun Zhang*. 2018. Dietary sodium butyrate improves intestinal development and function by modulating the microbial community in broilers. PLoS ONE 13(5): e0197762.

Tan L, Rong D, Yang Y, Zhang B*. Effect of oxidized soybean oils on oxidative status and intestinal barrier function in broiler chickens. 2018. Brazilian Journal of Poultry Science. 20(2):333-342.

Tsai Pei-Yun#, Bingkun Zhang#, Wei-Qi He, Juan-Min Zha, Matthew A. Odenwald, Gurminder Singh, Atsushi Tamura, Le Shen, Anne Sailer, Sunil Yeruva, Wei-Ting Kuo, Yang-Xin Fu, Sachiko Tsukita, and Jerrold R. Turner. 2017. IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance. Cell Host & Microbe. 21(6): 671–681.

Shao Yu-Xin, Zhao Lei, Patricia G Wolf, Yan Gao, Yu-Ming Guo, and Bing-Kun Zhang*. 2017. Zinc Supplementation, via GPR39, Upregulates PKC zeta to Protect Intestinal Barrier Integrity in Caco-2 Cells Challenged by Salmonella enterica Serovar Typhimurium. The Journal of Nutrition. 147(7):1282-1289.

Shao Yuxin, Patricia G. Wolf, Shuangshuang Guo, Yuming Guo, H. Rex Gaskinsc, Bingkun Zhang*. 2017. Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells. Journal of Nutritional Biochemistry. 43: 18–26.

Shao Y., Z. Lei, J. Yuan,Y. Yang, Y. Guo, and B. Zhang*. 2014. Effect of zinc on growth performance, gut morphometry, and cecal microbial community in broilers challenged with Salmonella enterica serovar Typhimurium. J Microbiol. 52(12): 1002–1011.

Zhang B.#, Y. Shao, D. Liu, P. Yin, Y. Guo, and J. Yuan. 2012. Zinc prevents Salmonella enterica Serovar Typhimurium-induced loss of intestinal mucosal barrier function in broiler chickens. Avian Pathol. 41(4): 361-367.

Zhang Bingkun#, Li Haitao, Dongqin Zhao, Yuming Guo, Adriana Barri. 2011. Effect of fat type and lysophosphatidylcholine addition to broiler diets on performance, apparent digestibility of fatty acids, and apparent metabolizable energy content. Anim. Feed. Sci. Tech. 163: 177-184.

Zhang Bingkun#; X. Yang; Y. Guo; F. Long. 2011. Effects of dietary lipids and Clostridium butyricum on serum lipids and lipid-related gene expression in broiler chickens. Animal. 5(12): 1909-1915.

Zhang B. K.#, and Y. M. Guo. 2009. Supplemental zinc reduced intestinal permeability by enhancing occludin and ZO-1 expression in weaning piglets. Brit. J. Nutr.102(5): 687–693.

荣誉及奖励

张炳坤，袁建敏.以雏鹰俱乐部作为技术依托的创新创业人才培养模式. 全国农业专业学位研究生实践教学成果奖二等奖. 2018.10.17. 全国农业专业学位研究生教育指导委员会.

肉鸡健康养殖的营养调控与饲料高效利用技术. 呙于明(#); 张日俊; 李绍钰; 吕明斌; 袁建敏; 郝国庆; 杨鹰; 魏凤仙; 张炳坤; 王忠. 国家科学技术奖励工作办公室,国家科技进步二等奖, 2011.12.23.