赵丽红

赵丽红，动物营养与饲料科学博士，中国农业大学副教授，博士生导师。美国北卡罗来纳州立大学博士后，访问学者。动物营养学国家重点实验室成员，国家蛋鸡产业技术体系成员。中国毒理学饲料毒物学学会会员，中国畜牧兽医学会动物营养学分会会员；《中国畜牧杂志》、《动物营养学报》、《Journal of Integrative Agriculture》、《Journal of Cleaner Production》等杂志审稿专家。研究方向为霉菌毒素生物降解及微生态饲料添加剂研发，家禽营养与饲料安全。主持国家自然科学基金3项、北京市自然科学基金1项，高等学校博士学科点专项科研基金1项，大北农青年学者研究计划项目1项，十三五重点研发计划项目子课题主持1项，重点研发计划国际合作交流项目1项。参与十二五国家科技支撑计划项目、973计划等项目8项。申请国家发明专利18项，已获授权9项，发表SCI论文35篇（通讯和第一作者13篇）。科研成果“饲料主要霉菌毒素生物降解剂的创制与应用”，获2017年北京市科学技术进步二等奖（3/15）；“饲料主要霉菌毒素生物降解剂的创制与应用”，获2017年中国产学研合作创新成果奖一等奖（3/7）、2018年度全国商业科技进步奖一等奖（3/15）、2018年度中国发明创业成果奖一等奖（3/6）；“猪优质高效养殖关键技术研究与应用”，获2017年福建省科技进步三等奖（4/5）、神农福建农业科技奖科学研究成果一等奖（4/15）、2018年中国产学研合作创新成果奖二等奖（4/7）、；“霉菌毒素生物降解机理及饲料污染控制技术”获2014-2015年度中华农业科技奖科研成果一等奖(排名4/20)。获得2018年第二届中国畜牧兽医学会动物营养学分会青年学者讲坛优秀奖。获中国农业大学2019届本科生“百篇优秀毕业论文（设计）”优秀指导教师奖。目前培养硕士研究生7名（毕业2名）、博士研究生2名。

主要科研工作：

[1]    国家自然科学基金项目：CotA漆酶定向进化、降解黄曲霉毒素B1作用机理及动物解毒效果研究，编号31972604，经费59万元，执行年限2020.01-2023.12，主持人；

[2]    国家自然科学基金项目：玉米赤霉烯酮降解酶的基因克隆、外源表达及解毒特性研究，编号31772637，经费71.52万元，执行年限2018.01-2021.12，主持人；

[3]    国家自然科学基金项目：枯草芽孢杆菌ANSB01G对饲料中玉米赤霉烯酮生物降解机制的研究，编号31301981，经费24万元，执行年限2014.01-2016.12，主持人；

[4]    十三五国家重点研发计划项目：畜禽重大疫病防控与高效安全养殖综合技术研发---畜禽养殖绿色安全饲料饲养新技术研发，项目编号2018YFD0500600，执行年限2018.06-2020.12，子课题主持；

[5]    十三五国家重点研发计划项目国际合作项目：基于神经-内分泌-免疫网络的肉鸡应激分子机制研究，项目编号2017YFE0129900，执行年限2017.12-2020.12，参加；

[6]    中国农业大学基本科研业务费专项资金项目:呕吐毒素降解菌的筛选及作用机理研究,项目编号2019TC239，执行年限2019.01-2019.11，主持人；

[7]    北京市自然基金：降解单端孢霉烯族毒素有益微生物的筛选、解毒作用机理及动物应用效果的研究,项目编号6132021，经费14万元，执行年限2013.03-2015.12，主持人；

[8]    高等学校博士学科点专项科研基金：降解呕吐毒素有益菌的筛选及其在饲料单端孢霉烯族毒素降解中的应用,课题编号20120008120001，执行年限2012.12-2015.12，主持人；

[9]    中国农业大学基本科研业务费专项资金项目：降解玉米赤霉烯酮微生物的筛选及仔猪试验效果研究，项目编号2011JS004，执行年限2011.6-2012.12，主持人；

[10]大北农青年学者研究计划:牛奶中黄曲霉毒素M1生物消减及防控技术，执行年限2016.01-2017.12，主持人；

[11]横向课题：饲用抗生素替代物研发及优质无抗日粮配制技术，项目编号201905410410323，执行年限 2019.04-2024.4，主持人；

[12]横向课题国际合作项目：酵母细胞壁对青年母猪玉米赤霉烯酮中毒症的作用效果，项目编号201504810411064，执行年限 2015.01-2017.12，主持人；

[13]横向课题：抗菌肽替代抗生素对肉鸡生产性能、免疫功能及肠道健康的作用效果，项目编号201305410410322，2013.03-2015.03，主持人；

[14]横向课题：抗菌肽（普乐特）对肉鸡生产性能、免疫功能及肠道健康的作用效果，项目编号201705410410169， 2017.03-2019.03，主持人；

[15]横向课题：抗菌肽（普乐特）在育肥猪上应用效果的研究，项目编号201805410410137， 2017.09-2021.09，主持人；

[16]蛋鸡现代产业技术体系建设项目（编号CARS-40-K08），团队成员，研究方向动物营养需要与饲料，经费50万元，2016-2020，参加人；

[17]十二五国家科技支撑计划项目，新型微生态制剂的创制与应用，项目编号2013BAD10B02，执行年限2013.05-2016.05，参加人；

[18]十二五国家科技支撑计划项目，新型饲料用酶制剂创制与应用，科技支撑项目（编号2013BAD10B01），2013-2016，参加人；

[19]单端孢霉烯族毒素生物降解菌引进、优化，948项目（编号2013-Z20），2013.1-2013.12，参加人；

[20]黄曲霉毒素解毒酶基因的克隆及在毕赤酵母中的表达，国家自然基金（编号31072063），2011-2013，参加人；

发表文章情况：

[1]    Yongpeng Guo, Yong Zhang, Chen Wei, Qiugang Ma, Cheng Ji, Jianyun Zhang, Lihong Zhao*. Efficacy of Bacillus subtilis ANSB060 Biodegradation Product for the Reduction of the Milk Aflatoxin M1 Content of Dairy Cows Exposed to Aflatoxin B1. Toxins, 2019,11,161.（IF5=4.009）

[2]    Yongpeng Guo, Xueting Huo, Lihua Zhao, Qiugang Ma, Jianyun Zhang, Cheng Ji, Lihong Zhao*. Protective effects of Bacillus subtilis ANSB060, Bacillus subtilis ANSB01G and Devosia sp. ANSB714 based mycotoxin biodegradation agent on mice fed with naturally contaminated diets. Probiotics and Antimicrobial Proteins.2019.

https://link.springer.com/content/pdf/10.1007/s12602-019-09606-w.pdf （IF5=2.411）

[3]    Jinglin Ma, Lihua Zhao, Dandan Sun, Jing Zhang, Yongpeng Guo, Zhiqiang Zhang, Qiugang Ma, Cheng Ji, Lihong Zhao*. Effects of Dietary Supplementation of Recombinant Plectasin on Growth Performance, Intestinal Health and Innate Immunity Response in Broilers. Probiotics and Antimicrobial Proteins.2019.https://doi.org/10.1007/s12602-019-9515-2（IF5=2.411）

[4]    Liyuan Zhang, Qiugang Ma, Shangshan Ma, Jianyun Zhang, Ru Jia, Cheng Ji, Lihong Zhao*. Ameliorating Effects of Bacillus subtilis ANSB060 on Growth Performance, Antioxidant Functions, and Aflatoxin Residues in Ducks Fed Diets Contaminated with Aflatoxins. Toxins.2017, 9, 1.  (IF5=3.551)

[5]    Ru Jia, Qiugang Ma, Yu Fan, Chen Ji, Jianyun Zhang, Tao Liu, Lihong Zhao*. The toxic effects of combined aflatoxins and zearalenone in naturally contaminated diets on laying performance, egg quality and mycotoxins residues in eggs of layers and the protective effect of Bacillus subtilis biodegradation product. Food and Chemical Toxicology. 2016,90:142-150.  (IF5=3.628)

[6]    Yongpeng Guo, Jianchuan Zhou, Yu Tang, Qiugang Ma,Jianyun Zhang, Cheng Ji, Lihong Zhao*.  Characterization and Genome Analysis of a Zearalenone‑Degrading Bacillus velezensis Strain ANSB01E. Current Microbiology. 2019. https://doi.org/10.1007/s00284-019-01811-8

[7]    Lihong Zhao, Xiaoying Li, Cheng Ji ,Xiaoping Rong, Shujing Liu, Jianyun Zhang, Qiugang Ma. Protective effect of Devosia sp.ANSB714 on growth performance, serum chemistry, immunity function and residues in kidneys of mice exposed to deoxynivalenol. Food and Chemical Toxicology. 2016,92:143-149.  (IF5=3.628)

[8]    Lihong Zhao, Yuanpei Lei, Yinghui Bao, Ru Jia, Qiugang Ma, Jianyun Zhang, Jun Chen, Cheng Ji. Ameliorative effects of Bacillus subtilis ANSB01G on zearalenone toxicosis in prepubertal female gilts. Food additives and contaminats-Part A. 2015,32(4):617-625(9).  (IF5=2.398)

[9]    Yu Fan, Lihong Zhao（并列）, Cheng Ji, Xiaoying Li , Ru Jia, Lin Xi, Jianyun Zhang, Qiugang Ma. Protective Effects of Bacillus subtilis ANSB060 on Serum Biochemistry, Histopathological Changes and Antioxidant Enzyme Activities of Broilers Fed Moldy Peanut Meal Naturally Contaminated with Aflatoxins. Toxins. 2015, 7(8):3330-3343.   (IF5=3.942)

[10]C. Ji, Y. Fan and L. H. Zhao. Review on biological degradation of mycotoxins. Animal Nutrition. 2016, 2:127-133.

[11]Xiaoying Li, Yongpeng Guo, Lihong Zhao, Yu Fan, Cheng Ji , Jianyun Zhang, Qiugang Ma. Protective effects of Devosia sp. ANSB714 on growth performance, immunity function, antioxidant capacity and tissue residues in growing-finishing pigs fed with deoxynivalenol contaminated diets. Food and chemical toxicology. 2018,12:246-251. (IF5=4.248)

[12]Yu Fan,Laiting Liu, Lihong Zhao, Xinping Wang, Dacai Wang, Churan Huang, Jianyun Zhang, Cheng Ji, and Qiugang Ma. Influence of Bacillus subtilis ANSB060 on growth, digestive enzyme and aflatoxin residue in Yellow River carp fed diets contaminated with aflatoxin B1. Food and Chemical Toxicology. 2018,113: 108-114.  (IF5=4.248)

[13]Donghui Shi, Jianchuan Zhou, Lihong Zhao, Xiaoping Rong, Yu Fan, Humera Hamid, Wenqiang Li, Cheng Ji, Qiugang Ma. Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts. Journal of Animal Science and Biotechnology. 2018,9:42. (IF5=3.903)

[14]Xiaoying Li, Lihong Zhao（并列）, Yu Fan, Yaxiong Jia, Lei Sun, Shanshan Ma, Cheng Ji, Qiugang Ma and Jianyun Zhang. Occurrence of mycotoxins in feed ingredients and complete feeds obtained from the Beijing region of China. Journal of Animal Science and Biotechnology. 2014,5:37-45.   (IF=3.205)

[15]Yuanpei Lei, Lihong Zhao（并列）, Qiugang Ma, Jianyun Zhang, Tin Zhou, Chunqi Gao, Cheng Ji. Degradation of zearalenone in swine feed and feed ingredients by Bacillus subtilis ANSB01G. World Mycotoxin Journal. 2014,7(2):143-151.  (IF5=1.873)

[16]Yu Fan, Lihong Zhao（并列）, Qiugang Ma, Xiaoying Li, Huiqin Shi, Tin Zhou, Jianyun Zhang, Cheng Ji. Effects of Bacillus subtilis ANSB060 on growth performance, meat quality and aflatoxin residues in broilers fed moldy peanut meal naturally contaminated with aflatoxins. Food and Chemical Toxicology. 2013,59:748-753.  (IF=3.282)

[17]Lihong Zhao, Shu Guan，Xin Gao, Qiugang Ma, Yuanpei Lei, Xiumei Bai, Cheng Ji. Preparation, purification and characteristics of an aflatoxin degradation enzyme from Myxococcus fulvus ANSM068. Journal of Applied Microbiology. 2011,110(1):147-155.  (IF5=2.658)

[18]Shu Guan, Lihong Zhao（并列）, Ting Zhou, Ning Wang, Xinxu Hu, Cheng Ji. In vitro efficacy of Myxococcus fulvus ANSM068 to biotransform aflatoxin B1. International Journal of Molecular Science. 2010,11:4063-4079.  (IF5=2.118)

[19]H. Hamid, L. H. Zhao, G. Y. Ma, W. X. Li, H. Q. Shi, J. Y. Zhang, C. Ji, Q. G. Ma(通讯). Evaluation of the overall impact of antibiotics growth promoters on broiler health and productivity during medication and withdrawal period. Poultry Science.2019, 98: 3685–3694.  (IF5= 2.537)

[20]Y. J. Liu, L. H. Zhao, R. Mosenthin, J. Y. Zhang, C. Ji, Q. G. Ma.Protective Effect of Vitamin E on laying performance, antioxidant capacity, and immunity in laying hens challenged with Salmonella Enteritidis. Poultry Science. 2019, 98: 5847-5854.  (IF= 2.518)

[21]Gao X, Ma QG, Zhao LH, Lei YP, Shan YJ, Ji C. 2011. Isolation of Bacillus subtilis: screening for aflatoxins B1, M1,and G1 detoxification. Eur Food Res Technol (232):957-962.

[22]Liu C, Zhang JY, Li ML, Zhao LH, Ji C and Ma QG. Alterations and structural resilience of the gut microbiota under dietary fat perturbations. Journal of nutritional biochemistry. 2018, 61:91-100.(IF5= 4.808)

[23]T. Liu, Q. G. Ma, L. H. Zhao, R. Jia, J. Y. Zhang, C. Ji and X. Y. Wang. Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B1. Toxins 2016, 8, 278.(IF5= 3.450)

[24]Qiugang Ma, Yan Li, Yu Fan, Lihong Zhao, Hua Wei, Cheng Ji, Jianyun Zhang. 2015. Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin B1-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers. Toxins 2015, 7, 5435–5447.  IF5=3.942

[25]Qiugang Ma , Yan Li , Yu Fan , Lihong Zhao , Hua Wei , Cheng Ji  and Jianyun Zhang. Effects of Lipoic Acid on Immune Function, the Antioxidant Defense System, and Inflammation-Related Genes Expression of Broiler Chickens Fed Aflatoxin Contaminated Diets. International journal of molecular sciences, 2014,15:5649-5662.

[26]Li, Y., Ma, Q.G., Zhao, L.H., Guo, Y. Q., Duan, G. X., Zhang, J.Y. and Ji, C. (2014) Protective Efficacy of Alpha-lipoic Acid against AflatoxinB1-induced Oxidative Damage in the Liver. Asian-Australas Jounal of Animal Science.

[27]Qiugang Ma, Xin Gao, Ting Zhou, Lihong Zhao, Yu Fan, Xiaoying Li, Yuanpei Lei, Cheng Ji, Jianyun Zhang. 2012. Protective effect of Bacillus subtilis ANSB060 on egg quality, biochemicaland histopathological changes in layers exposed to aflatoxin B1. Poultry Sci 91:2852-2857.

[28]H. Hamid, L. H. Zhao（并列）, G. Y. Ma, W. X. Li, H. Q. Shi, J. Y. Zhang, C. Ji, Q. G. Ma. Evaluation of the overall impact of antibiotics growth promoters on broiler health and productivity during medication and withdrawal period. Poultry Science.2019, 98: 3685–3694.  (IF= 2.518)

[29]Han XJ, Qin P, Li WX, Ma QG, Ji C, Zhang JY, Zhao LH. Effect of sodium selenite and selenium yeast on performance, egg quality, antioxidant capacity, and selenium deposition of laying hens. Poultry Science 2017,96(11):3973-3980.

[30]Gao CQ, Ji C, Zhang JY, Zhao LH, Ma QG. 2013. Effect of a novel plant phytase on performance, egg quality, apparent ileal nutrient digestibility and bone mineralization of laying hens fed corn–soybean diets. Anim Feed Sci Tech 186(1):101-105.

[31]Gao CQ, Ji C, Zhao LH, Zhang JY, Ma QG. 2013. Phytase transgenic corn in nutrition of laying hens: Residual phytase activity and phytate phosphorus content in the gastrointestinal tract. Poultry Sci 92(11):2923-2929.

[32]Jie Y, Zhang J, Zhao L, Ma Q, Ji C. 2013. The correlationship between the metabolizable energy content, chemical composition and color score in different sources of corn DDGS. Journal of animal science and biotechnology 4(1):38.

[33]Ma Q, Gao C, Zhang J, Zhao L, Hao W, Ji C. 2013. Detection of transgenic and endogenous plant DNA fragments and proteins in the digesta, blood, tissues, and eggs of laying hens fed with phytase transgenic corn. PloS one 8(4):e61138.

[34]Gao C, Ma Q, Zhao L, Zhang J, Ji C. 2014. Effect of Dietary Phytase Transgenic Corn on Physiological Characteristics and the Fate of Recombinant Plant DNA in Laying Hens. Asian Australia. J. Anim. Sci 27(1):77-82.

[35]Bai XM, Ma QG, Zhao LH, Xi L, Ji C. 2011. Effects of alpha-lipoic acid supplementation on antioxidative ability and performance of sows and nursing piglets. J Anim Physiol an N. 96:955-961.

[36]Peng Chen, Qiugang Ma, Cheng Ji, Jianyun Zhang, Lihong Zhao, Yong Zhang, Yongze Jie. 2011. Dietary lipoic acid influences antioxidant capability and oxidative status of broilers. International Journal of Molecular Sciences 12(12):8476-8488.

[37]Zhang Y, Ma QG, Bai XM, Zhao LH, Wang Q, Ji C, Liu LT, Yin HC. 2010. Effects of dietary acetyl-L-carnitine on meat quality and lipid metabolism in Arbor Acres broilers. Asian Austral J Anim 23(12):1639-1644.

[38]Hu XX, Hongtrakul K, Ji C, Ma QG, Guan S, Song CL, Zhang Y, Zhao LH. 2009. Effect of carnosine on growth performance, carcass characteristics, meat quality and oxidative stability in broiler chickens. Journal of Poultry Science 46(4):296-302.

[39]H. Hamid, J. Y. Zhang, W. X. Li, C. Liu, M. L. Li, L. H. Zhao, C. Ji, Q. G. Ma.Interactions between the intestinal microbiota and nonalcoholic steatohepatitis using laying hens as the model. Poultry Science. 2019, 98: 2509–2521.  (IF= 2.518)

正在申请的专利：

[1]    赵丽红，马秋刚，计成，郭永鹏.一种同时降解玉米赤霉烯酮和黄曲霉毒素的贝莱斯芽孢杆菌.中国农业大学. 申请号：201911186458.X.申请日:2019.11.20.

[2]    国际专利PCT：赵丽红，马秋刚，计成，郭永鹏.细菌漆酶CotA蛋白在降解霉菌毒素中的应用.中国农业大学. 申请号：PCT/CN2019/095955.申请日:2019.7.15.

[3]    赵丽红，马秋刚，计成，郭永鹏.细菌漆酶CotA蛋白在降解霉菌毒素中的应用.中国农业大学. 申请号：201811492897.9.申请日:2018.12.07.

[4]    赵丽红，张建云，马秋刚，郑雅文，郭永鹏. 吡咯喹啉醌在缓解脂多糖诱导的动物细胞和肠道炎症上的应用.中国农业大学. 申请号：201910554679.1.申请日:2019.06.25.

[5]    赵丽红，计成，马秋刚，张静，郭永鹏.一种降解呕吐毒素的耐盐海杆菌及其应用. 中国农业大学.申请号：201910630182.3.申请日:2019.07.12

[6]    赵丽红，郭永鹏，秦晓娟，郑雅文，马景林，张琼琼. 一种利用微生物酶氧化催化AFB1制备AFQ1及epi-AFQ1的方法. 中国农业大学.申请号：201910700119.2.申请日: 2019.7.31

[7]    赵丽红，郭永鹏，格桑白拇，马秋刚，秦晓娟，张静.一种降解展青霉素的产朊假丝酵母、生物制剂及其应用.中国农业大学.申请号：201910744674.5.申请日:2019.8.13

[8]    计成，马秋刚，赵丽红，贾如.由枯草芽孢杆菌分泌的黄曲霉毒素降解酶及其应用.中国农业大学.申请号 : CN201610703221.申请日 : 2016.08.22

[9]    赵丽红，马秋刚，计成，张建云.一种评价微生物降解饲料黄曲霉毒素效率的方法. 中国农业大学