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郑世军

社会职务：中国农业大学特聘教授、博士生导师

所在单位：中国农业大学

基本信息

研究领域：农学

职称：

所在单位：中国农业大学

入库日期：2020-02-06

简介

基本情况

郑世军，免疫学博士，中国农业大学特聘教授、博士生导师，国家杰出青年基金获得者，新世纪百千万人才工程国家级人选，中国农科院教学名师，获国务院特殊专家津贴。

l研究领域
目前主要从事抗感染免疫的分子机理以及畜禽传染病免疫防制的研究。

l工作经历
2005年7月-至今中国农业大学特聘教授，预防兽医学教授，兼任农业生物技术国家重点实验室研究员
 2000年12月-2005年6月博士后，美国宾夕法尼亚大学
 1996年8月-2000年12月研究助理，美国麻省大学
 1993年1月-1996年8月讲师，中国农业大学
 1990年7月-1993年1月助教，中国农业大学

l教育背景
2000年12月-2005年6月博士后，美国宾夕法尼亚大学
 1996年8月-2000年12月博士，美国麻省大学
 1987年9月-1990年7月硕士，中国农业大学
 1982年9月-1987年7月学士，中国农业大学

l学术兼职
中国农学会理事会理事
中国免疫学会北京市免疫学分会理事
中国畜牧兽医学会动物传染病学分会常务理事
农业生物技术国家重点实验室研究员
全国动物疫病防控专家委员会委员

国家兽医药典委员

 

l主要发表论文

 

  1. Fu M, Wang B, Chen X, He Z,Wang Y, Li X,Cao H,Zheng SJ.  gga-miR-454 suppressesinfectious bursal disease  virus (IBDV) replication via directly      targetingIBDV genomic segment B and cellular   Suppressors of Cytokine Signaling 6 (SOCS6). Virus Research 2018 May  16. 252, 29-40. doi: 10.1016/j.virusres.2018.05.015.

  2. Wang B, FuM, Liu Y, WangY, LiX,Cao H, andZheng SJ*gga-miR-155 Enhances Type I Interferon Expression and Suppresses      Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK. Frontier  in Cellular and Infection Microbiology 2018, March 7, 8(55); 1-13, doi: 10.3389/fcimb.2018.00055

  3. Chen X, He Z,FuM,WangY, Wu H,LiX,Cao H, and Zheng SJ *The E3 ubiquitin ligase Siah-1 suppresses      avian reovirus infection by targeting p10 for degradation, J Virology 2018 , Jan 10.92(6). pii: e02101-17. doi:      10.1128/JVI.02101-17.

  4. Wang   B, DuanX, FuM, Liu Y, WangY,LiX,Cao H, and   Zheng SJ* The Association of  Ribosomal Protein L18 (RPL18)  with IBDV VP3 Enhances Viral Replication, Virus Research 2018,Feb 2;245:69-79.

  5. He Z, Chen X, Fu M, Tang J,  Li  X,Cao H,  Wang Y, andZheng SJ*. Infectious bursal disease   virus protein VP4 suppresses, type I interferon expression via inhibiting      K48-linked ubiquitylation of glucocorticoid-induced leucine zipper (GILZ), Immunobiology  2018,Apr – May, 223(4-5):374-382.

  6. FuM, Wang B,  ChenX, He Z, WangY, Li X,CaoH, andZheng SJ*,gga-miR-130b suppresses infectious  bursal disease virus replication via targeting the viral genome and  cellular SOCS5, J Virology 2017 Dec 14;92(1). pii: e01646-17. doi: 10.1128/JVI.01646-17. Print 2018 Jan 1.

  7. Qin Y, Xu Z, Wang Y, LiX,CaoH, and Zheng SJ*, VP2 of  Infectious Bursal Disease Virus induces apoptosis via triggering Oral  Cancer Overexpressed 1 (ORAOV1) protein degradation. Frontiers in Microbiology2017, July, 8(1):doi: 10.3389/fmicb.2017.01351

  8. Li X, Liu Y, Wang Y,Liu J, LiXQ,  Cao H, GaoX andZheng SJ*,Negative  regulation of hepatic inflammation by the Soluble Resistance-Related      Calcium Binding Protein via STAT3. Frontier  in Immunology2017, June 29, 8: 1-14 (doi:      10.3389/fimmu.2017.00709)

  9. Qin Y andZheng SJ*.Infectious Bursal Disease  Virus-Host Interactions: Multifunctional Viral Proteins that Perform Multiple and Differing Jobs. International  J of Molecular Sciences2017,18, 161;  doi:10.3390/ijms18010161

  10. Xu Z, Qin Y, Wang Y, LiX,CaoH, and Zheng SJ*,A Critical role of bacterioferritin inSalmonella pullorum-inducedIFN-β expression in DF-1 cells, Frontiers in Microbiology2016, 7(1):doi: 10.3389/fmicb.2016.00020

  11. Wu H, H Z, Tang J, LiX,CaoH, Wang Y*, andZheng SJ*      A critical role of LAMP-1 in avian reovirus P10 degradation associated with inhibition of apoptosis and  virus release. Arch Virol2016,161:899–911

  12. Lin W, Zhang Z, Xu  Z, Wang B, Li XQ,Cao H, Wang Y*, andZheng SJ*. The  Association ofReceptor of Activated Protein Kinase C 1（RACK1）with Infectious Bursal Disease Virus Protein VP5 and  VDAC2 Inhibits Apoptosis and Enhances Viral Replication. J Biol Chem. 2015, 290(13): 8500-10.

  13. Zhang Z, Lin W, Wu  H, Li XQ,Cao H, Wang Y*,andZheng SJ*, Critical Roles of Eukaryotic  Elongation Factor 1 alpha(eEF1A1) in      Avian Reovirus Sigma C-induced Apoptosis and Inhibition of Viral Growth.Archives  of Virology2015, 160:1449–1461.

  14. Zheng W, Li X, Wang J, Li XQ,Cao H, Wang Y, Zeng Q*, andZheng SJ*. A critical role of interferon-induced protein IFP35 in Foot-and-Mouth Disease Virus(FMDV)  protein2C-induced  type I interferon response in cells.Archives of Virology 2014,159(11):2925-35.

  15. Guo Z,Stephenson R,Qiu J,Zheng SJ,Luo ZQ.A Legionella effector modulates host cytoskeletal structure by inhibiting actin polymerization, Microbes infect. 2014, 16(3):225-36.

  16. Li X， Wang J，Liu J，Li Z， Wang Y，Xue Y, Li XQ,Cao  H, andZheng SJ*. Engagement of Soluble Resistance-Related Calcium Binding Protein (sorcin) with foot-and-mouth disease virus (FMDV) VP1 inhibits type I interferon response in cells, Vet Microbiology2013，166: 35–46. 

  17. Li Z, Wang Y, Li X, Li XQ,Cao H, andZheng SJ*. Critical Roles of Glucocorticoid-Induced Leucine Zipper in Infectious Bursal Disease Virus (IBDV)-induced Suppression of Type I Interferon Expression and Enhancement of IBDV Growth in Host Cells via Interaction with VP4.J Virology2013, 87(2):1221-1231.

  18. Li X, Li XQ,Cao H, Wang Y, andZheng SJ*. Engagement ofnew castle disease virus (NDV) matrix (M) protein with charged multivesicular body protein (CHMP) 4 facilitates viral replication. Virus Research 2013, 171: 80-88.

  19. Wang J, Wang Y, Liu J, Ding L, Zhang Q, Li X,Cao  H, Tang J, andZheng SJ*. A critical role of N-myc and STAT interactor (Nmi) in foot-and-mouth disease virus (FMDV)2C-induced apoptosis.Virus Research 2012, 170 (2012) 59– 65.

  20. Luo Z, Li Z, Chen K, Liu R, Li X,Cao H, andZheng SJ*. Engagement of Heterogeneous Nuclear Ribonucleoprotein M with Listeriolysin O Induces Type I Interferon Expression and Restricts Listeria Monocytogenes Growth in Host Cells. Immunobiology2012, 217(10): 972-981.

  21. Li Z, Wang Y, Xue Y, Li X,Cao H, andZheng SJ*. A critical role for voltage-dependent anion channel (VDAC)2  in infectious bursal disease virus (IBDV)-induced apoptosis in host cells via interacting with VP5.J Virology2012, 86(3): 1328-1338.

  22. Ruan W, Wu Y,Zheng SJ*.Different genetic patterns in avian Toll-like receptor (TLR)5 genes.Mol Biol Rep. 2012，39（4）3419-26.

  23. Ruan WK, Wu YH, An J, Cui DF, Li HR,Zheng SJ*. Toll-like receptor 2 type 1 and type 2 polymorphisms in different chicken breeds.Poultry Science. 2012, Jan; 91(1):101-6.

  24. Li LJ., Cui D.,Zheng SJ., Lou HJ., Tang J. Regulation of Actinomycin D induced upregulation of Mdm2 in H1299 cells.DNA Repair (Amst) 2012,11(2):112-9.

  25. Ruan Q, Kameswaran V, Zhang Y,Zheng S, Sun J, Wang J, Devirgiliis J, Liou HC, Beg AA, Chen YH. The Th17 immune response is controlled by the Rel-ROR{gamma}-ROR{gamma}T transcriptional axis.J Exp Med. 2011 Oct 24; 208 (11):2321-33.

  26. Ruan WK,Zheng SJ*. Polymorphisms of chicken toll-like receptor 1 type 1 and type2 in different breeds.Poultry Science2011, Sep; 90(9):1941-7.

  27. Li H, Li X, Lu Y, Wang X, Zheng SJ*. Staphylococcus sciuri exfoliative toxin C is a dimer that modulates macrophage functions.Can. J. of Microbiology2011, 57: 722-729.

  28. Li H, Wang Y, Ding L, andZheng SJ*. Staphylococcus sciuri exfoliative toxin C (ExhC) is a necrosis-inducer for mammalian cells. PLoS ONE 2011, 6 (7): e23145: 1-9.

  29. Li H, He F, Zhang Z,Zheng SJ*. Critical roles of amino acids Ser231, His107 and Asp156 of Staphylococcus sciuri exfoliative toxin C (ExhC) in the induction of skin exfoliations of neonate.Biologia2011: 90-11C

  30. Chen K, Luo Z, Tang J,Zheng SJ*. A critical role of heat shock cognate protein70 in Apoptin-induced phosphorylation of Akt. Biochem Biophys Res Commun. 2011 Jun 3; 409(2):200-4.

  31. Chen K, Luo Z,Zheng SJ*. Gallus Heat shock cognate protein 70, a novel binding partner of Apoptin.Virol J. 2011 Jun 27; 8: 324-333.

  32. Lianghai Wang, Hexiao Zhang, Xiong Suo,Shijun Zheng, Wen-hai Feng. Increase of CD163 but not sialoadhesin on cultured peripheral blood monocytes is coordinated with enhanced susceptibility to porcine reproductive and respiratory syndrome virus infection.Veterinary Immunology and Immunopathology 2011 141: 209–220.

  33. Ruan Q,Zheng SJ, Palmer S, Carmody RJ, Chen YH. Roles of Bcl-3 in the pathogenesis of murine type 1 diabetes.Diabetes 2010, Oct; 59(10):2549-57.

  34. Pang P, Chen FY, Tang J, Ma LF, Wang JC,Zheng SJ*. Avian leukosis virus p27 inhibits tumor necrosis factor αexpression in RAW264.7 macrophages after stimulation with lipopolysaccharide.Acta Virologica 2010, 54:119-124.

  35. Wang L, Suo X，Chen Y andZheng SJ* Expression of Newcastle disease virus (NDV) M protein from a recombinant plasmid prolongs the survival of NDV-infected chicken embryos and enhances the virus replication.Acta Virologica 2009, 53:105-110.

  36. Cheng W, An L, Wu Z, Zhu Y, Liu J, Gao H, Li, XZheng SJ, Chen D and Tian J. Effects of disulfide bond reducing agents on sperm chromatin structural integrity and developmental competence of in vitro matured oocytes after intracytoplasmic sperm injection in pigs.Reproduction 2009, 137: 633–643.

  37. Wang Y, Lu Y, Duo Y, Wang Y,Chen F,Yang H, Zheng SJ*.Enhanced resistance of restraint stressed mice to sepsis.Journal of Immunology 2008, 181:3441-3448.

  38. Shi K, Li H, Guo X, Ge X, Jia H, Zheng SJ, Yang H. Changes in peripheral blood leukocyte subpopulations in piglets co-infected experimentally with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2.Veterinary Microbiology 2008, 22;129(3-4):367-77.

  39. Chen S, Wang Y, Chen F, Yang H, Menghou Gan andZheng SJ*. A highly pathogenic strain of Staphylococcus sciuri caused fatal exudative epidermitis in piglets.PLoS ONE 2007, 2(1)e147: 1-6.

  40. Hilliard A, Hilliard B,Zheng SJ, Sun H, Takashi M, Song W and Chen YH. Translational regulation of autoimmune inflammation and lymphoma by programmed cell death 4. Journal of Immunology 2006,177 (11):8095-8102.

  41. Zheng SJ,L-Cherradi S, Wang P, Xu LY and Chen YH. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function.Diabetes 2005, 54: 1423-1428.

  42. Zheng SJ, Jiang J., Shen H., and Chen YH.Reduced apoptosis and listeriosis in TRAIL-null mice.Journal of Immunology2004, 173: 5652-5658.

  43. Zheng SJ, Wang P., Tsabary G. and Chen YH. Critical role of TRAIL in hepatic cell death and hepatic inflammation.Journal of Clinical Investigation2004, 113(1): 58-64.

  44. L-Cherridi S*, Zheng SJ*(*Co-first author), Maguaschak, KA and Chen YH. Defective thymocyte apoptosis and accelerated autoimmunune diseases in TRAIL-Null mice.Nature Immunology2003, 4(3): 255-260.*Note: The first two authors contributed equally to this study.

  45. L-Cherradi S,Zheng SJ and Chen YH. Critical role of tumor necrosis factor-related apoptosis-inducing ligand in type I diabetes.Diabetes 2003, 52: 2274-2278.

  46. Zheng SJ and Chen YH. TRAIL, Bim and thymic negative selection.Immunological Research2003, 28/3: 293-299.

  47. L-Cherradi S,Zheng SJ, Hilliard BA, Xu L, Sun J, Alsheadat S and Chen YH. Transcriptional regulation of type I diabetes by nuclear factor-KB.Journal of Immunology 2003, 171:4886-4892.

  48. 柳亚楠，王永强，李晓齐，曹

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