文莹

文莹，教授，博士研究生导师。1999年6月获中国农业大学微生物学博士学位，毕业后留校任教。2002.6–2004.6在日本国立食品综合研究所做博士后，从事黄曲霉毒素生物合成基因簇中基因功能的研究。2004年底被聘为中国农业大学副教授，2015年1月被聘为中国农业大学教授。

简历：

1987/09–1991/07 北京农业大学生物学院微生物系，理学学士

1991/07–1994/09 北京农业大学京农公司，科研助理

1994/09–1999/07 中国农业大学生物学院微生物系，理学博士（硕博连读）

1999/07-2004/12 中国农业大学生物学院微生物系，讲师

2002/06–2004/06 日本国立食品综合研究所细胞功能实验室，博士后

2004/12–2014/12 中国农业大学生物学院微生物学与免疫学系，副教授

2015/01–今中国农业大学生物学院微生物学与免疫学系，教授

主要研究方向：

目前主要从事链霉菌抗生素生物合成调控机理、代谢工程育种和产抗生素链霉菌的发酵研究。

发表论文（*通讯作者；！共同第一作者）：

2017

Sun D, Wang Q, Chen Z, Li J, Wen Y*. An alternative σ factor, σ⁸, controls avermectin production and multiple stress responses in Streptomyces avermitilis. Frontiers in Microbiology. 2017 Apr; 8: 736.

2016

Zhu J, Sun D, Liu W, Chen Z, Li J, Wen Y*. AvaR2, a pseudo γ-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth.Mol Microbiol. 2016 Nov; 102(4): 562-578.

Sun D,Zhu J,Chen Z, Li J, Wen Y*. SAV742, a novel AraC-family regulator from Streptomyces avermitilis, controls avermectin biosynthesis, cell growth and development.Scientific Reports. 2016Nov; 6: 36915.

2015

Zhang Q, Chen Q, Zhuang S, Chen Z, Wen Y*, Li J. A marR family transcriptional regulator, DptR3, activates daptomycin biosynthesis and morphological differentiation in Streptomyces roseosporus.Appl Environ Microbiol. 2015 Jun; 81(11): 3753-65.

LiuW, ZhangQ, Guo J, Chen Z, Li J, Wen Y*.Increasing avermectin production in Streptomyces avermitilis by manipulating the expression of a novel TetR-family regulator and its target gene product.Appl Environ Microbiol. 2015 Aug;81(15): 5157-73.

Yang R, Liu X, Wen Y, Song Y, Chen Z*, Li J. The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis. Appl Microbiol Biotechnol. 2015 Dec;99(24): 10547-57.

2014

He F, Liu W, Sun D, Luo S, Chen Z, Wen Y*, Li J. Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis.Appl Microbiol Biotechnol. 2014 Jan; 98(1): 399-409.

Guo J, Zhang X, Chen Z, Wen Y*, Li J.Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis. PLoS One. 2014 Jun 10; 9: e99224.

Luo S, Sun D, Zhu J, Chen Z, Wen Y*, Li J. An extracytoplasmic function sigma factor, σ²⁵, differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis. Appl Microbiol Biotechnol. 2014 Aug; 98(16): 7097-112.

2013

Liu Q, Xin Y, Liu H,Zhou Y,WenY*.Nocardioides szechwanensesp. nov. and Nocardioides psychrotolerans sp. nov., isolated from Hailuogou glacier in Szechwan, P. R. China. Int J Syst Evol Microbiol.2013 Jan; 63(Pt 1): 129-33.

Guo J, Zhang X, Luo S, He F, Chen Z, Wen Y*, Li J. A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. PLoS One. 2013 Aug 13; 8(8): e71330.

Liu Y, Yan T, Jiang L, Wen Y, Song Y, Chen Z*, Li J. Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis. J Bacteriol. 2013 Oct; 195(19): 4365-72.

2012

Zhang X, Chen W, Zhang Y, Jiang L, Chen Z, Wen Y*, Li J. Deletion of ku homologs increases gene targeting frequency in Streptomyces avermitilis. J Ind Microbiol Biotechnol. 2012 Jun; 39(6): 917-25.

2011

Jiang L, Liu Y, Wang P, Wen Y, Song Y, Chen Z*, Li J. Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis. Biotechnol Lett. 2011 Oct;33(10):1955-61.

2010

Li M, Chen Z, Zhang X, Song Y, Wen Y*, Li J. Enhancement of avermectin and ivermectin production by overexpression of the maltose ATP-binding cassette transporter in Streptomyces avermitilis. Bioresour Technol. 2010 Dec; 101(23): 9228-35.

Chen W, He F, Zhang X, Chen Z, Wen Y*, Li J. Chromosomal instability in Streptomyces avermitilis: major deletion in the central region and stable circularized chromosome. BMC Microbiol. 2010 Jul 26; 10:198.

Li L, Guo J, Wen Y*, Chen Z, Song Y, Li J. Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains. J Ind Microbiol Biotechnol. 2010 Jul; 37(7): 673-9.

Guo J, Zhao J, Li L, Chen Z, Wen Y*, Li J. The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. Mol Genet Genomics. 2010 Feb; 283(2): 123-33.

2009

Lin X, Wen Y, Li M, Chen Z, Guo J, Song Y, Li J*. A new strain of Streptomyces avermitilis produces high yield of oligomycin A with potent anti-tumor activity on human cancer cell lines in vitro. Appl Microbiol Biotechnol. 2009 Jan; 81(5): 839-45.

2008

Li M, Chen Z, Lin X, Zhang X, Song Y, Wen Y, Li J*. Engineering of avermectin biosynthetic genes to improve production of ivermectin in Streptomyces avermitilis. Bioorg Med Chem Lett. 2008 Oct 15; 18(20): 5359-63.

2007

Chen Z, Wen J, Song Y*, Wen Y, Li J. Enhancement and selective production of avermectin B by recombinants of Streptomyces avermitilis via intraspecific protoplast fusion. Chin Sci Bull. 2007 May; 52(5): 616-22.

Zhao J, Wen Y, Chen Z, Song Y, Li J*.An adpA homologue in Streptomyces avermitilis is involved in regulation of morphogenesis and melanogenesis. Chin Sci Bull. 2007May; 52(5): 623-30.

2006

Zhang X, Chen Z, Li M, Wen Y, Song Y, Li J*. Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis.Appl Microbiol Biotechnol. 2006 Oct; 72(5): 986-94.

2005

Wen Y, Hatabayashi H, Arai H, Kitamoto HK, Yabe K*. Function of the cypX and moxY genes in aflatoxin biosynthesis in Aspergillus parasiticus. Appl Environ Microbiol. 2005 Jun; 71(6): 3192-8.

Sakuno E！, Wen Y！, Hatabayashi H, Arai H, Aoki C, Yabe K*, Nakajima H. Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis. Appl Environ Microbiol. 2005 Jun; 71(6): 2999-3006.

编写教材：

文莹、李颖主编，现代微生物研究技术，中国农业大学出版社, 2008年10月。

李颖、文莹、关国华等译，李季伦、宋大康校，微生物生理学(第4版，中文版)，高等教育出版社，2009年8月。

李颖、关国华主编，李季伦主审，微生物生理学，科学出版社，2013年4月。参编12.5万字/108万字。

王磊、陈芝主编，文莹主审，微生物遗传学实验教程，科学出版社，2014年6月。

论

教改论文：

李颖*，王颖，陈文峰，田杰生，文莹，何群. 生物学理科基地微生物学课程互动式教学，微生物学通报，2010, 37(1): 123-126.